She then appeared in 2001's Blow, opposite Johnny Depp and Ray Liotta. In 2001, Griffiths was cast as one of the leads in Six Feet Under. Her performance as emotionally scarred massage therapist, Brenda Chenowith, earned her Golden Globe and Screen Actors Guild Awards, as well as two Emmy Award nominations. In the third season, she missed four episodes due to her first pregnancy.
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